Tetraspanins (Tspans) comprise a membrane protein family structurally defined by four transmembrane domains and intracellular N and C termini that is found in almost all cell types and tissues of eukaryotes. Moreover, they are involved in a bewildering multitude of diverse biological processes such as cell adhesion, motility, protein trafficking, signaling, proliferation, and regulation of the immune system. Beside their physiological roles, they are linked to many pathophysiological phenomena, including tumor progression regulation, HIV-1 replication, diabetes, and hepatitis. Tetraspanins are involved in the formation of extensive protein networks, through interactions not only with themselves but also with numerous other specific proteins, including regulatory proteins in the central nervous system (CNS). Interestingly, recent studies showed that Tspan7 impacts dendritic spine formation, glutamatergic synaptic transmission and plasticity, and that Tspan6 is correlated with epilepsy and intellectual disability (formerly known as mental retardation), highlighting the importance of particular tetraspanins and their involvement in critical processes in the CNS. In this review, we summarize the current knowledge of tetraspanin functions in the brain, with a particular focus on their impact on glutamatergic neurotransmission. In addition, we compare available resolved structures of tetraspanin family members to those of auxiliary proteins of glutamate receptors that are known for their modulatory effects.
Cysteine-rich receptor-like-kinases (CRKs), a transmembrane subfamily of receptor-like kinase, play crucial roles in plant adaptation. As such cotton is the major source of fiber for the textile industry, but environmental stresses are limiting its growth and production. Here, we have performed a deep computational analysis of CRKs in five Gossypium species, including G. arboreum (60 genes), G. raimondii (74 genes), G. herbaceum (65 genes), G. hirsutum (118 genes), and G. barbadense (120 genes). All identified CRKs were classified into 11 major classes and 43 subclasses with the finding of several novel CRK-associated domains including ALMT, FUSC_2, Cript, FYVE, and Pkinase. Of these, DUF26_DUF26_Pkinase_Tyr was common and had elevated expression under different biotic and abiotic stresses. Moreover, the 35 land plants comparison identified several new CRKs domain-architectures. Likewise, several SNPs and InDels were observed in CLCuD resistant G. hirsutum. The miRNA target side prediction and their expression profiling in different tissues predicted miR172 as a major CRK regulating miR. The expression profiling of CRKs identified multiple clusters with co-expression under certain stress conditions. The expression analysis under CLCuD highlighted the role of GhCRK057, GhCRK059, GhCRK058, and GhCRK081 in resistant accession. Overall, these results provided primary data for future potential functional analysis as well as a reference study for other agronomically important crops.
Objective: To analyse the clinicopathological spectrum of COVID-19 among 2000 patients. Study Design: Cross-sectional study. Place and Duration of Study: Combined Military Hospital, Abbottabad Pakistan, from Apr to Jun 2020. Methodology: The study included 2000 patients who came to CMH Abbottabad to seek medical attention during the first wave of the COVID-19 pandemic. Age, gender, contact history, history of foreign travel, clinical features, comorbid conditions and results of SARS-CoV-2 PCR were observed. Results: From 2000 cases, 1442(72%) were males, and 558(28%) were females. The mean age was 35.02±13.00 years, and 1275(63.8%) cases were from the 3rd to fourth decade of life. 900(45%) of the cases had a contact history with a COVID-19 patient, whereas only 4(0.2%) had a history of foreign travel. 1854(93.0%) of the cases were asymptomatic, whereas only 48(2.4%) presented with fever and cough, the most common symptoms. Only 26(1.3%) cases had associated comorbid conditions, and 263(13.0%) cases showed positive PCR results. The statistical association was found to be significant among age groups, gender, contact history and results of SARS-CoV-2 PCR,(p-value< 0.001). Conclusion: This study provides an overall view of the COVID-19 pandemic, which has grasped the globe within no time.Efficient preventive and control measures are mandatory, in addition to early identification and diagnosis, to overcome the infection.
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