Background:The roles of PP5 in normal biology are poorly understood. Results: To help evaluate the biological actions of PP5, a Cre/loxP-conditional mouse line was generated. Conclusion: In response to UV light, PP5 regulates the phosphorylation of Chk1 at Ser-345. Significance: Understanding the biological roles for phosphatases is critical for understanding the role of reversible phosphorylation in the control of signaling networks.
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