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Background-The cytokine-deficiency induced colitis susceptibility (Cdcs)1 locus is a major modifier of murine IBD and was originally identified in experimental crosses of interleukin-10-deficient (Il10 −/− ) mice. Congenic mice, in which this locus was reciprocally transferred between IBD-susceptible C3H/HeJBir-Il10 −/− and resistant C57BL/6J-Il10 −/− mice, revealed that this locus likely acts by inducing innate hypo-and adaptive hyperresponsiveness, associated with impaired NFKB responses of macrophages. The aim of the present study was to dissect the complexity of Cdcs1 by further development and characterization of reciprocal Cdcs1 congenic strains and to identify potential candidate genes in the congenic interval.

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Frankia strain CcI3 grown in culture produced a hemoglobin which had optical absorption bands typical of a hemoglobin and a molecular mass of 14.1 kDa. Its equilibrium oxygen binding constant was 274 nM, the oxygen dissociation rate constant was 56 s−1, and the oxygen association rate constant was 206 μM−1 s−1.