Background: ESCRT-III can enhance Vta1 stimulation of Vps4 ATPase activity via the Vps4 stimulatory element (VSE) of Vta1. Results: ␣7 and ␣9 of the Vps4 small AAA domain mediate VSE stimulation, contributing to Vps4 function in vivo. Conclusion: Vta1 contacts Vps4 ␣7 and ␣9 during ESCRT-III-enhanced stimulation of Vps4. Significance: These studies identify a novel mechanism of Vps4 stimulation.
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