Although the study was underpowered for the reported associations to reach formal threshold of genome-wide significance under the assumption of independent multiple testing, the consistency of association between the 2 variants and a set of anthropometric traits makes CRIM1 and ITGA1 highly interesting for further replication and functional follow-up. Increased linkage disequilibrium between the used markers in an isolated population makes the formal significance threshold overly stringent, and changed allele frequencies in isolate population may contribute to identifying variants that would not be easily identified in large outbred populations.

The impact of the COVID-19 pandemic in sport has been the subject of numerous studies over the past two years. However, knowledge about the direct impact of COVID-19 infection on the performance of athletes is limited, and the importance of studies on this topic is crucial during the current pandemic era. This study aimed to evaluate the changes in the match running performance (MRP) of professional soccer players that occurred as a result of COVID-19 infection after fulfilling all of the prerequisites for a safe return to play (RTP). The participants were 47 professional soccer players from a team which competed in first Croatian division (21.6 years old on average) during the 2020/21 season. The total sample was divided into two subgroups based on the results of a PCR test for COVID-19, where 31 players tested positive (infected) and 16 tested negative. We observed the PCR test results (positive vs. negative PCR), the number of days needed to return to the team, number of days needed to RTP after quarantine and isolation, and MRP (10 variables measured by a global positioning system). The number of days where the infected players were not included in the team ranged from 7 to 51 (Median: 12). Significant pre- to post-COVID differences in MRP for infected players were only found for high-intensity accelerations and high-intensity decelerations (t-test = 2.11 and 2.13, respectively; p < 0.05, moderate effect size differences), with poorer performance in the post-COVID period. Since a decrease of the MRP as a result of COVID-19 infection was only noted in two variables, we can highlight appropriateness of the applied RTP. However, further adaptations and improvements of the RTP are needed with regard to high-intensity activities.

Abbreviations: ECG, electrocardiography; CVVHDF, continuous veno-venous hemo dia filtration; ARDS, acute respiratory distress syndrome IntroductionGlyphosate-surfactant herbicide is one of the most frequently used herbicides. Glyphosate kills plants by suppressing the shikimic metabolic pathway. 1 The mechanism of toxicity of glyphosate in mammals has been proposed to be the uncoupling of oxidative phosphorylation.2 Surfactants are inert ingredients that are added to herbicides to precisely increase the absorption of the active component. Surfactants may contribute to the toxicity of the active substance.1 An experiment in dogs found that hypotension is primarily caused by myocardial depression with surfactant. 3 The ingestion of small amounts of glyphosate-surfactant herbicide usually causes only mild symptoms. However, when large volumes of concentrates are ingested intentionally, it can generate potentially fatal symptoms that are refractory to the treatment. 4 The treatment for glyphosatesurfactant herbicide poisoning is primarily of a supportive nature. 5Early continuous veno-venous hemodiafiltration (CVVHDF) contributes to the survival. 4,6 Case reportAt noon, a 45-year-old man deliberately drank a ½-liter of glyphosate-surfactant herbicide (trade name Cidokor). Cidokor is formulated as a liquid concentrate for solution and contains 480g/ L±24g/L (41.5% approx. weight) monoizopropylamine glyphosate salt (monoizopropylamine salt of N-phosphonomethyl-glycine). Other ingredients include ethoxylated fatty amines (mixture of n-alkyl (C 14 +C 16 +C 18 )-N, N, -bis (poliethoxylated) fatty amines 176g/L±11g/L (15.5% approx. weight). Cidokor is manufactured by Monsanto Europe SA, Brussels, Belgium. Immediately after drinking the poison, his wife gave him a few deciliters of milk to drink. For many years, the patient had suffered from psychosis, which was recently in a deterioration (paroxetine and risperidone were not taken regularly). He consumed alcohol. After poisoning he was transported by boat from the island to the hospital. He was admitted into the Gastroenterology Department at 3 p.m. Upon admission, he was conscious, complained of pain in the throat and epigastric area. Treatment was started, and diuresis was stimulated by furosemide. Hyperkalemia was corrected with an infusion of glucose and insulin, sodium bicarbonate and calcium gluconate. The patient received pantoprazole, amiodarone and oxygenation through a facemask with a bag. Despite treatment, his consciousness deteriorated into a coma (Glasgow coma score 3), and the patient demonstrated dilated pupils and no reaction to light. Chest X-rays showed confluent opacities and the development of ARDS. Cardiovascular collapse developed (blood pressure 80/50mmHg). Anuric acute renal failure, hyperkalemia and metabolic acidosis also developed. ECG showed progressive hyperkalemia. Nasogastric retention of bloody content was large. Rhabdomyolysis developed. For further treatment, he was admitted to the intensive care unit. Orotracheal intubation was performe...

Nastavni zavod za javno zdravstvo Splitskodalmatinske županije, Split,

No abstract