Sebaceous carcinoma is a rare cutaneous malignancy which is typically regarded as relatively aggressive and has traditionally been subdivided into periorbital or extraorbital tumours. We conducted a retrospective review of all cases of sebaceous carcinoma reported to the Western Australian Cancer Registry between 1987 and May 2019. The incidence of sebaceous carcinoma in Western Australia has increased over the last three decades, with extraorbital tumours being much more common than periorbital tumours. Very few sebaceous carcinomas have led directly to the death of patients; however, adverse outcomes were more likely with periorbital tumours, in particular local recurrence and the need for major surgical intervention.
A 74-year-old man presented with a 3-month history of severe cutaneous erosions involving his scalp, chest, back, arms and legs, which had gradually progressed (Fig. 1a). These were accompanied by oral mucositis (Fig. 1b) with a reduction in oral intake, and consequent weight loss and malnutrition. The patient's medical history included prostate cancer [Gleason grade 6 (3 + 3)], for which he had elected to refuse treatment, as well as emphysema and psoriasis in childhood. His tumour was localized to the prostate gland with stable prostate-specific antigen level (11 ng/mL) and no evidence of metastatic disease on computed tomography scan (chest, abdomen and pelvis) or bone scintigraphy. Serum anti-skin antibodies (intercellular) were detected. Biopsies were taken on two separate occasions, both of which revealed similar histological features.Clinicopathological case
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.