The persistence of PPI was defined as number of days to discontinuation of index PPI treatment without a gap of 30 or more days. Persistent PPI use for ≤ 8 weeks was classified as short term user and for > 8 weeks was classified as a long term PPI user. Descriptive statistics were performed to characterize the study population. Generalized linear models were used to analyze the cost difference and bootstrapping analysis was conducted to compute the 95% Confidence Interval (CI) as per percentile method. A statistical significance level of 0.05 was used in the study. SAS 9.3 software was used for statistical analysis. Results: The study population consisted of 75,503 patients with a GERD indication and incident PPI use. Majority of the patients were females (58.2%) and mean age of the cohort was 47.8 years. On an average, long term PPI users had higher all cause total costs
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