Tenosynovial giant cell tumor (TSGCT) is a highly recurrent benign tumor of the extremities. Wide local excision is usually sufficient to achieve its recurrence-free outcome. However, that needs a confident pre-operative cytological diagnosis as TSGCT. Aspirates from this tumor express the characteristic polymorphic cytological pattern, enough to impose a definite diagnosis. However rarely so, inadequate sampling from smaller tumors or due to faulty techniques, and selective sampling from topographic clusters of any individual component may lead to wrong interpretation. An unorthodox location near the larger limb joints further complicates the diagnostic misery on occasions. Such tumors are amenable to incomplete removal and risk for future recurrence. In this report, we describe eight cases of TSGCTs that were cytologically diagnosed otherwise. The cytological features of these discrepant tumors and the factors attributable to such dilemma are elaborated. Finally, a possible remedy has been proposed at conclusion in order to avoid future inconveniences.

Background: Coagulation parameters are essential part of clinical and laboratory workup, Pre-Analytical variables like collection, anticoagulation, transportation, storage and hematocrit all effect coagulation parameters tests and accuracy of results, like PT, APTT and fibrinogen. As transportation and storage effecting time and temperature are very variable, they can interfere with the results of coagulation parameters. Aim: To study the effect of time on coagulation parameters PT, APTT, and Fibrinogen at Room temperature. Materials and Methods: The study population consisted of 70 adult asymptomatic patients 18 years or older. Sample in 3.2% citrate vials with blood to citrate ratio 9:1 were run in automatic analyser (Stago compact) and results were recorded. Statistical analyses were performed using GraphPad QuickCalcs .Results: PT and Fibrinogen did not have clinically relevant changes up to 24 hours and APTT upto 4 hours at Room temperature Conclusion:, PT and Fibrinogen measurement could be safely stored for upto 24 hours at Room temperature, while APTT can only be stored upto 4 hours at Room temperature.

BACKGROUND Endometriosis is defined as the presence of ectopic endometrial tissue outside the uterine cavity and is characterized by recurrent episodes of pelvic pain and dysmenorrhea. The high prevalence of the disease along with its recurrent persistent nature poses a significant burden on the healthcare system of a country. Considering the enormity of the healthcare burden and the impact it has on the quality of life of the patients, here was a need to develop a marker which may help in the definitive diagnosis of this dreadful disease. The aim of this study is to corroborate the histopathological diagnosis of endometriosis with the immunohistochemical staining for CD10 and to find out the diagnostic efficacy of CD10 for endometriosis among clinically diagnosed patients of endometriosis. METHODS Patients admitted with suspected endometriosis and planned for operation in the Department of Gynaecology and Obstetrics, at North Bengal Medical College and Hospital in that year who gave informed consent for the study were included in the study provided they satisfied the inclusion and exclusion criteria. A representative histological block from each of the biopsy specimen harvested during the surgery of patients of endometriosis was chosen for immunohistochemistry for CD10. Correlation of CD-10 antigen expression was done with the post-operative histopathological findings. RESULTS Immunohistochemistry with CD10 increased the diagnostic yield of endometriosis cases. Cases diagnosed as endometriosis by routine histopathology were found to be positive for CD10. In others, CD10 positivity was also seen in those characterised by haemorrhagic cysts and endometriotic stroma. CONCLUSIONS CD10 immunostaining can be used to give a definitive diagnosis in cases where previously the pathologist would report as being "consistent with endometriosis" even in the absence of endometrial epithelium. We strongly recommend the use of CD10 IHC to confirm or exclude the diagnosis in cases of presumptive endometriosis and in those mistaken for this entity.

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