Background:The transcription factor TBX3 regulates the anti-proliferative function of the TGF-1 pathway but its downstream target(s) responsible for this is unknown. Results: TBX3 downstream of TGF-1 signaling represses TBX2 to inhibit proliferation.
Conclusion:The down-regulation of TBX2 is required for the anti-proliferative function of the TGF-1-TBX3 axis. Significance: This study sheds light on the mechanisms involved in the anti-proliferative role of TGF-1.
Overexpression of the developmentally important T-box transcription factor TBX3 inhibits proliferation but promotes the migration of epithelial cells. TBX3 is transcriptionally up-regulated by the TGF-β1 signaling pathway in a Smad3/4- and JunB-dependent manner and is a key mediator of the antiproliferative and promigratory roles of TGF-β1.
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