Background: Improvement in short term outcomes after kidney transplant has been achieved by using different induction and maintenance therapeutic approaches. Long term outcomes have not matched the expectations of the transplant stakeholders. Our study aimed to address the early impact of induction agents on long term outcome of kidney transplant when measured by Iothalamate clearance. Methods: All adult kidney transplant recipients between January of 2012 and December of 2016 were reviewed. 649 patients were divided into three groups based on the induction agent (Basiliximab, Alemtuzumab, and Thymoglobulin). Protocoled 4 months and 48 months kidney allograft function evaluation with Iothalamate clearance test were compared among the three groups. Results: Patients who received Basiliximab were significantly older with no difference among African American and Caucasians. The 48 months assessment showed significant decline in median Iothalamate clearance in Basiliximab group at 49 ml/min vs. Alemtuzumab group 64.8 ml/min and Thymoglobulin 60 ml/min with p = 0.007. The Basiliximab group developed a significant higher proteinuria measured by spot urine to creatinine ratio at 48 months. Conclusions: The use of Basiliximab as an induction agent for kidney transplant is associated with significant decline in kidney function 5 years post-transplantation when measured by Iothalamate clearance.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.