Human cytomegalovirus (HCMV) infects 50% of adults in the United States. HCMV can become a cause for concern in individuals who have a compromised immune system, which may occur after high-intensity exercise. The purpose of this preliminary study was to characterize the lymphocyte, monocyte, and neutrophil responses to exercise in HCMV+individuals. Participants were either positive (HCMV +) or negative (HCMV-) for HCMV. Participants visited the laboratory on 3 separate occasions: HCMV screening, 100% VO2max test, and 80% VO2max run. Mixed-model factorial ANOVA procedures with repeated measures on sampling condition were performed on absolute and relative circulating lymphocytes, monocytes, and neutrophils. Significant main effects for time for both absolute and relative values were seen for all leukocyte subsets regardless of virus status. Significant differences for absolute and relative values were seen between sampling conditions for all leukocyte subsets. We report for the first time that HCMV status does not affect circulating neutrophil responses to high-intensity exercise, though exercise-induced neutrocytosis is seen during the post-exercise and 60 min post-exercise sampling conditions, regardless of HCMV status. There is no HCMV effect on circulating monocyte responses to exercise, though exercise-induced monocytosis was seen during the post-exercise sampling condition regardless of HCMV status.
Common tenrecs, Tenrec ecaudatus, are small tropical hibernating mammals endemic to Madagascar. Tenrecs possess many phenotypic features associated to ancestral mammals, suggesting they may act as a model of an ancestral form of hibernation. Common tenrecs are able to hibernate at ambient temperatures ranging from 12 to 28 °C and do not undergo brief periodic returns to euthermy during the hibernation season, a shared feature among all other known hibernators. Tenrecs display extreme metabolic flexibility. For instance, they can spontaneously enter torpor during the active season, termed facultative torpor (FT). During both hibernation and FT, oxygen consumption rates have been observed to be 1–14% of active rates depending on ambient temperatures. Protein metabolism may account for 30% or more of standard oxygen consumption rates for most animals. Polysome profiles were used to determine the status of translation in tenrecs as a function of core body temperature (Tb) and activity state. Our findings will provide mechanistic data that will be used to elucidate how common tenrecs are able to regulate metabolic flux exclusive of Tb.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.