Objective: There remain inconclusive findings from previous observational epidemiological studies on whether consumption of artificially-sweetened soft drinks (ASSDs) increases the risk of gastrointestinal (GI) cancer. We investigated the associations between the consumption of ASSDs and the risk of GI cancer using a meta-analysis. Design: Systematic review and meta-analysis. Setting: PubMed and EMBASE were searched using keywords until May 2020 to identify observational epidemiological studies on the association between the consumption of ASSDs and the risk of GI cancer. Subjects: Twenty-one case-control studies and 17 cohort studies with 12,397 cancer cases and 2,474,452 controls. Results: In the random-effects meta-analysis of all the studies, consumption of ASSDs was not significantly associated with the risk of overall GI cancer (odds ratio (OR)/relative risk (RR), 1.02; 95% CI, 0.92-1.14). There was no significant association between the consumption of ASSDs and the risk of overall GI cancer in the subgroup meta-analyses by study design (case-control studies: OR, 0.95; 95% CI, 0.82-1.11; cohort studies: RR, 1.14; 95% CI, 0.97-1.33). In the subgroup meta-analysis by type of cancer, consumption of ASSDs was significantly associated with the increased risk of liver cancer (OR/RR, 1.28; 95% CI,1.03-1.58). Conclusions: The current meta-analysis of observational epidemiological studies suggests that overall, there is no significant association between the consumption of ASSDs and the risk of GI cancer.
Background: Research into aetiologies and prevention of the commonest cancers and implementation of primary and secondary prevention can reduce cancer risk and improve quality of life. Moreover, monitoring the prevalence of cancer risk factors in a specific population helps guide cancer prevention and early detection efforts and national cancer control programming. Objective: This article aims to provide the scope and findings of cancer risk studies conducted in Uganda to guide researchers, health-care professionals, and policymakers. Methods: Between November 2019 to January 2020, we searched peer-reviewed published articles in Pubmed, EMBASE and Cochrane Library (Cochrane central register of controlled trials-CENTRAL). We followed the recommendation of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses – the PRISMA. The primary focus was to identify cancer risk and prevention studies conducted in Uganda and published in peer-reviewed journals from January 2000 and January 2020. We used key Boolean search terms with their associated database strings. Results: We identified 416 articles, screened 269 non-duplicate articles and obtained 77 full-text articles for review. Out of the 77 studies, we identified one (1%) randomized trial, two (2.5%) retrospective cohort studies and 14 (18%) case-control studies, 46 (60%) cross-sectional studies, five (6.4%) ecological studies, three panel studies (4%) and six (8%) qualitative studies. Cervical cancer was the most studied type of cancer in Uganda (23.4%, n = 18 studies), followed by lymphomas – both Hodgkin and Non-Hodgkin sub-types (20.7%), n = 16 studies) and breast cancer (15.6%, n = 12 studies). In lymphoma studies, Burkitt lymphoma was the most studied type of lymphoma (76%, n = 13 studies). The studies concentrated on specific cancer risk awareness, risk perceptions, attitudes, uptake of screening, uptake of human papillomavirus vaccination, the prevalence of some of the known cancer risk factors and obstacles to accessing screening services. Conclusion: The unmet need for comprehensive cancer risk and prevention studies is enormous in Uganda. Future studies need to comprehensively investigate the known and putative cancer risk factors and prioritize the application of the higher-hierarchy evidence-generating epidemiological studies to guide planning of the national cancer control program.
Background: Long non-coding RNAs (lncRNAs) are involved in the pathology of various tumors, including gastric cancer (GC). The crosstalk between tumor-associated macrophages (TAMs) and cancer cells in the tumor microenvironment promotes tumor development and confers chemoresistance, yet the contribution of lncRNAmediated crosstalk between TAMs and GC cells to tumor chemoresistance is not well understood. In this study, we further investigated the underlying tumor-promoting roles of LINC00184 and as molecular mediators involved in these processes.
Introduction. Lung cancer (LC) is the leading cause of cancer incidence among men and third most frequent case in women in the Philippines. LC incidence rates, overall and by histologic subtype, vary substantially by sex and smoking prevalence. The study aimed to analyze time trends in LC incidence in the Philippines over the 10-year period. There is no published report regarding trends of LC incidence by histologic subtype in the Philippines. Herein, we provide model-based estimates of limited time LC cases by histologic subtype from year 2003-2012. Methodology. Data for calculating LC incidence rates in 2003-2012 were obtained from the nationwide population-based Department of Health- Rizal Cancer Registry. Joinpoint regression was used to analyze trends and estimate annual percentage change (APC) with 95% confidence intervals (CI) on LC incidence by histologic subtype, time- period, sex, and geographical location, calculated incidence counts, rates per 100,000 person-years. 2000 - 2015 population used in calculating ASR of LC incidence where taken from Philippines Statistics Authority (PSA), and each annual population from 2003 - 2012 where estimated using exponential function by extrapolation. Results. LC incidence shows increasing average annual rates in the past 10 years, observed rate overall (19.5), male (27.0) and female (12.1). Among LC specified histologic subtype, adenocarcinoma (ADC) contributes highest rate, in men (9.8) and women (5.5), followed by squamous cell carcinoma (SQCC), in men (3.6) and women (0.6). Incidence trend declines to both sexes in 2007, and increases thereafter, in men (APC: 13.7, 95% CI: -8.5; 41.3) and women (APC: 14.8, 95% CI: -10.0; 47.4). The highest increase in average annual percentage change (AAPC) among specified LC histologic subtype were observe to ADC, in men (APC: 6.5, 95% CI: -2.2; 16.1) and women (APC: 8.5, 95% CI: -1.4; 19.5). Along with SQCC to women's cohort were also remark high AAPC (APC: 6.7, 95% CI: -4.4; 19.0). From cohort 2003- 2007 carcinoma not otherwise specified which has the foremost number of cases among non-specified histologic subtype eventually decreased by half folds from cohort 2008-2012. In contrast, malignant neoplasm increase doubled in rate from each mentioned year-cohorts. Conclusion. The study revealed divergent LC trends by gender and histologic subtype, which were generally consistent from 2003-2012. Among LC histological subtypes, large increase in incidence was observed for ADC, which both genders showed an increasing trend for 10-year period. LC will always remain a serious public health issue in the Philippines such implementation of National Tobacco Control Policy should be prioritized in preventing smoking initiation and promoting smoking cessation, particularly among men. Citation Format: Jansen Marcos Cambia, Jin Kyoung Oh, Jayson Cagadas Pasaol. Divergent trends in lung cancer incidence by histologic subtype in Philippines, 2003-2012: A population-based study [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 1191.
Background: Palliative care in the Philippines is categorized as 3A, considered to have localized hospice care provision; however, lack of education and awareness are dismal and accounted as the biggest challenges for the health care providers and for their patients. Other barriers like access and referral to palliative care specialist were not even equitable for all, especially in the Southern Philippines. The pervasive stigma of what palliative care means to the health care provider remains the major problem for accessing palliative programs, particularly in pediatric oncology patients. Objectives: This study aimed to assess the level of knowledge, attitude, and practice of health care providers towards pediatric palliative care. It intended to discover the associated factors that limit the pediatric oncology patients to receive palliative care, and to identify the barriers in providing palliative care by the cancer centers to the pediatric oncology patients. Method: A cross-sectional study design was used to carry out the research study in the 500 respondents (100 oncology doctors, 250 medical nurses, and 150 allied health workers) using a systematic random sampling method at the 13 tertiary care hospitals that offer palliative care to pediatric oncology patients in the Southern Philippines. Structured questionnaire was circulated to identify the barriers of palliative care, and assess the knowledge, attitude, and practices (KAP) of health care providers using a systematic random sampling method. The data were entered, cleaned, and analyzed using Excel and SPSS version 19.0 software. The chi-square test was employed to assess the association between variables. A p-value of less than 0.05 was considered as statistically significant. Results: From the total of 508 health care providers selected, a response rate of 500 (98.4%) was registered. Among the respondents, 287 (57.4%) had good knowledge and 259 (58.1%) had favorable attitude towards pediatric palliative care. In contrast, the level of practice showed that the majority, 384 (76.8%) of health care providers, had poor practice towards palliative care. Results showed that 94% to 99% of health care providers believed that the inadequate research evidence base to guide and measure the quality of life and lack of staff training in pediatric palliative care were the major barriers in providing palliative care by the cancer centers to the pediatric oncology patients. In addition, 100% of health care providers affirmed that the ignorance and lack of awareness about the existing program and resources of palliative care were the major factors that limit the pediatric oncology patients in receiving pediatric palliative care in Southern Philippines. Conclusions: The health care providers had poor training and knowledge aspect of practice, but their attitude towards palliative care was favorable. Recommendations are the need to be incorporated in the Department of Health through Continuing Professional Development to promote regular training for palliative care. Citation Format: Jayson Cagadas Pasaol, Jashin Rosal, Jansen Marcos Cambia, Jin Kyoung Oh. Assessment of knowledge, attitude, and practice and associated factors towards palliative care among health care providers to the pediatric oncology patients in southern Philippines [abstract]. In: Proceedings of the AACR Special Conference on Environmental Carcinogenesis: Potential Pathway to Cancer Prevention; 2019 Jun 22-24; Charlotte, NC. Philadelphia (PA): AACR; Can Prev Res 2020;13(7 Suppl): Abstract nr A36.
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