Background: NKp30 is a major activating receptor of natural killer (NK) cells.
Results:The stalk domain of NKp30 increases ligand binding affinity, which is modulated by glycosylation of the ectodomain of NKp30.
Conclusion:The stalk domain and the glycosylation status of NKp30 are critical for NK cell killing. Significance: This is the first hint for a novel mode of receptor regulation.
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