In this paper, a periodically corrugated transmission line is proposed. The proposed transmission line can reduce crosstalk between transmission lines. The corrugated transmission line can adjust the amount of inductive coupling and capacitive coupling equally. Thus, the crosstalk is effectively reduced because the inductive coupling and capacitive coupling cancel each other. The corrugated transmission line is fabricated on RO4003 substrate with a dielectric constant of 3.38 and a thickness of 0.508 mm. The simulated far-end crosstalks of conventional transmission line and corrugated transmission line with a period of A=1 mm have maximum values of -3.6 dB and -22 dB, respectively, up to 30 GHz. Measurement results showed that far-end crosstalks of the conventional and corrugated transmission line have maximum values of -6.3 dB and -20.5 dB, respectively, up to 30 GHz.