Este artículo fue aprobado para publicación en el v68n3 de la Revista de la Facultad de Medicina teniendo en cuenta los conceptos de los pares evaluadores y los cambios realizados por los autores según estos conceptos. Por lo tanto, se publica la versión preliminar del artículo para su consulta y citación provisional, pero debe aclararse que esta puede diferir del documento final, ya que no ha completado las etapas finales del proceso editorial (corrección de estilo, traducción y diagramación) y solo los títulos, datos de autores, palabras clave y resúmenes corresponden a la versión final del artículo.Esta versión puede consultarse, descargarse y citarse según se indique a continuación, pero debe recordarse que el documento final (PDF, HTML y XML) puede ser diferente. Actividad neurotóxica del veneno de serpientes del género Micrurus y métodos para su análisis. Revisión de la literatura]. Rev. Fac. Med. 2020;68(3): In press -2020. English. doi: Neurotoxical activity of Micrurus snakes venom and methods for its analysis. A literature review. Rev. Fac. Med. 2020;68(3): In press -2020. English. doi: http://dx.doi.org/10.15446/revfacmed.v68n3.75992. Revista de la Facultad de MedicinaIn press publication Rev. Fac. Med. P u b l i c a c i ó n a n t i c i p a d a . R e v . F a c . M e d . Tipo de artículo: Artículo de revisión DOI: http://dx.doi.org/10.15446/revfacmed.v68n3.75992 Neurotoxical activity of Micrurus snakes venom and methods for its analysis. A literature review Actividad neurotóxica del veneno de serpientes del género Micrurus y métodos para su análisis. Revisión de la literatura Serpientes Micrurus: neurotoxicidad del veneno Abstract Introduction: Snakes of the genus Micrurus have fossorial habits, passive temperament and scarce production of powerful venom with neurotoxic characteristics that block the synaptic transmission at the neuromuscular junction. Objective: To present an overview of the neurotoxicity of the Micrurus snake venom, and its functional characterization by ex vivo analysis methods. Materials and methods: A literature review was conducted in MedLine and ScienceDirect using specific terms and their combinations. Search strategy: type of studies: articles on the neurotoxicity of Micrurus snake venom and techniques to determine its neurotoxic activity by in vitro, in vivo and ex vivo models; publication period: articles published until June 2018; publication language: English and Spanish.Results: Of 88 studies identified in the initial search, 28 were excluded because they did not meet the inclusion criteria (based on reading titles and abstracts). 8 additional articles (books and reports) were included, since, according to the authors' opinion, they complemented the information reported by the selected studies. The studies included in the review (n=68) were original research papers (n=44), review articles (n=16), and book chapters, reports, guides and online consultations (n=8). Conclusions:Studies performed using ex vivo muscle and nerve preparations to evaluate the effect of neurotoxins ...
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