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CALCIUM IN COMPLEMENT DEPENDENT HEMOLYSIS 179 and ocular defects. Multiple malformations were rare. The teratogenic dose of Congo red did not produce any alteration in maternal serum protein components during the expected period of teratogenic activity. This is contrasted to the situation found following treatment with trypan blue.

Summary Of a variety of naturally occurring and synthetic polynucleotides, only polyinosinic acid (poly I) is capable of evoking vascular permeability in guinea pig skin. This property of poly I is abolished by hydrogen-bonded helix formation with polyadenylic or polycytidylic acids, a maneuver which also destroys the capacity of poly I to interact with the complement system. The capacity of poly I to evoke vascular permeability is not affected by antihistamine. This biologic property of poly I supports previous evidence indicating that poly I can function as an activator of the first component of complement.