Canine parvovirus enteritis has remained a problem in dog population worldwide. In Nigeria, dog owners and researchers have grossly neglected the disease even though it has been a frequent cause of morbidity and mortality of dogs. This retrospective study provides current information on the status of canine parvovirus enteritis by collating and analyzing data from clinical records of hospitalized dogs from 2000 to 2013 in Effurun/Warri metropolitan region. In the study, the endemicity of this disease with an overall prevalence of 13.4% for the past 14 years has been demonstrated. The infection rates were significantly associated with age, sex, breed and vaccination status (P < 0.0001). Puppies from 0 to 5 months of age, male, breeds such as Alsatians, Mongrels, Rottweiler, indigenous dogs and unvaccinated dogs are at a higher risk. Furthermore, a seasonal pattern for the disease has been demonstrated with peak incidence recorded every 4-5 years with highest numbers of cases occurring in January (dry season) and July (wet season) of every year. Additionally, the study shows that a recovery rate of 84.3% was achieved following "aggressive'' therapeutic management. There is therefore a need to enlighten veterinarians and dog owners on the status and importance of vaccination against this disease.