Preincubation of normal rat soleus muscles in vitro with homogenates prepared from mixed leg muscles which had been denervated 4 days previously resulted in an increase in the contracture response to acetylcholine. After 30 min incubation a 1.5-fold increase was observed. Homogenates of normally innervated muscles did not increase the response. The active principles of the denervated muscles were found to reside in the "cytosol" fraction. An approximately 2-fold increase was observed upon incubation with the cytosol for 30 min; incubation for longer periods resulted in a subsequent decrease in the response. The effect of the denervated muscle cytosol was concentration-dependent and heat-labile. Normal muscle cytosol also increased the soleus muscle response to acetylcholine but this fraction was less effective than denervated muscle cytosol. The response of control muscles incubated in Krebs-Henseleit solution was found to decrease with time. Commercially obtained phospholipases C and D increased the response of normal soleus muscles approximatley 2-fold. Phospholipase A, lipase, trypsin, collagenase and a bacterial protease had no effect, lysozyme produced a small but consistent increase in the response to acetylcholine.
Health administration is an interdisciplinary profession practiced in various settings. This paper presents a core list of journals for libraries responsible for supporting the study or practice of health administration in any of these settings. This paper initially examines and defines the parameters of the field of health administration to guide in the selection and organization of the list of core health administration journals. The organization of the list is based on the definition of the field as presented in the paper. The most important journals have been indicated, and sufficient information is given to facilitate ordering.
Public health is a multidisciplinary field ranging broadly across the health care spectrum. In light of this diversity the selection of basic reference books and textbooks in the field is a complex task. This paper first defines the components of what is public health and then presents such a list to serve as a guide to the librarian faced with this task.
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