BackgroundThe mechanisms responsible for the associations between very preterm birth and a higher risk of poor cardiovascular and metabolic health in adult life are unknown.
MethodsComparison of the clinical and molecular phenotypes of healthy, normal weight young adults (18-27 years), born very preterm (<33 weeks gestational age (GA)) and at full-term (37-42 weeks GA).Outcomes included whole body magnetic resonance imaging; hepatic and muscle 1 H magnetic resonance spectroscopy; blood pressure (BP) measurement, urine and blood sampling and telomere length measurement.
ResultsWe recruited 156 volunteers, 69 born very preterm (45 women; 24 men) and 87 born at full-term (45 women; 42 men). Preterm men had significantly more internal-abdominal adipose tissue (mean difference 0.33L (95% CI 0.04, 0.62), p<0.05), significantly fewer long telomeres (145-48.5kb: preterm men 14.1 ± 0.9%, term men 17.8 ± 1.1%, p<0.05; 48.5-8.6kb: preterm men 28.2 ± 2.6, term men 37.0 ± 2.4%, p<0.001) and a significantly higher proportion of shorter telomeres (4.2-1.3kb: preterm men 40•4 ± 3.5%, term men 29.9 ± 3.2%, p<0.01) compared to full-term men.
ConclusionOur data indicate that healthy young adults born very preterm manifest clinical and molecular evidence of accelerated ageing.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.