Asymmetric copper-catalyzed allylic substitution with methylmagnesium bromide is employed in combination with ring-closing olefin metathesis or ene-yne metathesis to achieve the synthesis of chiral, unsaturated nitrogen heterocycles. The resulting six-to eight-membered chiral heterocycles are accessible in high yields and with excellent enantioselectivities.Nitrogen-containing heterocycles are ubiquitous in naturally occurring compounds, such as alkaloids, but are also key structural features in many biologically active products. 1-4 Among these, nitrogen heterocycles with various ring sizes bearing stereogenic centers are frequently observed. 5-10 For example, poisonous frogs produce a variety of biologically active chiral piperidines featuring methyl substituents at the stereocenters. 11,12 These structures represent interesting targets for synthesis, [13][14][15][16] imposing particular challenges with regard to the construction of the stereogenic centers with high selectivity. One approach that has been frequently exploited is the use of ring-closing metathesis for the construction of N-heterocycles, 14,[17][18][19] which has among
P u b l i c I n t e r e s t E n e r g y R e s e a r c h ( P I E R ) P r o g r a m F I N A L P R O J E C T R E P O R T CHARACTERIZING COSTS, SAVINGS AND BENEFITS OF A SELECTION OF ENERGY EFFICIENT EMERGING TECHNOLOGIES IN THE UNITED STATES California Energy Commission Anish Gautam Contract ManagerPramod Kulkarni Project Manager Virginia Lew Office Manager Energy Efficiency Research OfficeLaurie Ten Hope Deputy Director Energy Research, Development and Demonstration Division Melissa Jones Executive Director DISCLAIMERThis report was prepared as the result of work sponsored by the California Energy Commission. It does not necessarily represent the views of the Energy Commission, its employees or the State of California. The Energy Commission, the State of California, its employees, contractors and subcontractors make no warrant, express or implied, and assume no legal liability for the information in this report; nor does any party represent that the uses of this information will not infringe upon privately owned rights. This report has not been approved or disapproved by the California Energy Commission nor has the California Energy Commission passed upon the accuracy or adequacy of the information in this report.i The PIER Program conducts public interest research, development, and demonstration (RD&D) projects to benefit California. ACKNOWLEDGEMENTSThe PIER Program strives to conduct the most promising public interest energy research by partnering with RD&D entities, including individuals, businesses, utilities, and public or private research institutions.• PIER funding efforts are focused on the following RD&D program areas:• Buildings End-Use Energy Efficiency• Energy Innovations Small Grants EXECUTIVE SUMMARYImplementation and adoption of efficient end-use technologies have proven to be one of the key measures for reducing greenhouse gas (GHG) emissions throughout the industries. In many cases, implementing energy efficiency measures is among one of the most cost effective investments that the industry could make in improving efficiency and productivity while reducing CO 2 emissions. Over the years, there have been incentives to use resources and energy in a cleaner and more efficient way to create industries that are sustainable and more productive. With the working of energy programs and policies on GHG inventory and regulation, understanding and managing the costs associated with mitigation measures for GHG reductions is very important for the industry and policy makers around the world. Successful implementation of emerging technologies not only can help advance productivities and competitiveness but also can play a significant role in mitigation efforts by saving energy. Providing evaluation and estimation of the costs and energy savings potential of emerging technologies is the focus of our work in this project.The overall goal of the project is to identify and select emerging and under-utilized energy-efficient technologies and practices as they are important to reduce energy consumption in industry...
P u b l i c I n t e r e s t E n e r g y R e s e a r c h ( P I E R ) P r o g r a m I N T E R I M / F I N A L P R O J E C T R E P O R T Developing Information on Energy Savings and Associated Costs and Benefits of Energy Efficient Emerging Technologies Applicable in California California Energy Commission Anish Gautam Contract ManagerPramod Kulkarni Project Manager Virginia Lew Office Manager Energy Efficiency Research Office Laurie Ten Hope Deputy Director Energy Research, Development and Demonstration Division Melissa Jones Executive Director DISCLAIMERThis report was prepared as the result of work sponsored by the California Energy Commission. It does not necessarily represent the views of the Energy Commission, its employees or the State of California. The Energy Commission, the State of California, its employees, contractors and subcontractors make no warrant, express or implied, and assume no legal liability for the information in this report; nor does any party represent that the uses of this information will not infringe upon privately owned rights. This report has not been approved or disapproved by the California Energy Commission nor has the California Energy Commission passed upon the accuracy or adequacy of the information in this report.i The PIER Program conducts public interest research, development, and demonstration (RD&D) projects to benefit California. ACKNOWLEDGEMENTSThe PIER Program strives to conduct the most promising public interest energy research by partnering with RD&D entities, including individuals, businesses, utilities, and public or private research institutions.• PIER funding efforts are focused on the following RD&D program areas:• Buildings End-Use Energy Efficiency• Energy Innovations Small Grants EXECUTIVE SUMMARYImplementation and adoption of efficient end-use technologies have proven to be one of the key measures for reducing greenhouse gas (GHG) emissions throughout the industries. In many cases, implementing energy efficiency measures is among one of the most cost effective investments that the industry could make in improving efficiency and productivity while reducing carbon dioxide (CO2) emissions. Over the years, there have been incentives to use resources and energy in a cleaner and more efficient way to create industries that are sustainable and more productive. With the working of energy programs and policies on GHG inventory and regulation, understanding and managing the costs associated with mitigation measures for GHG reductions is very important for the industry and policy makers around the world and in California. Successful implementation of applicable emerging technologies not only may help advance productivities, improve environmental impacts, or enhance industrial competitiveness, but also can play a significant role in climate-mitigation efforts by saving energy and reducing the associated GHG emissions. Developing new information on costs and savings benefits of energy efficient emerging technologies applicable in California market is important for policy...
Chiral six‐ to eight membered N‐heterocycles are synthesized via the two‐step sequence.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.