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Patients and methods 460 patients with an average age of 64 years underwent 501 operations for non-spinal skeletal metastases. 7 % were operated for more than one metastasis. Carcinoma of the breast, prostate, kidney and lung were the dominating primary tumors.Results The survival rate was 0.4 at 1 year, 0.3 at 2 years and 0.2 at 3 years. Univariate analysis showed that survival was related to bone localization, skeletal metastatic load, presence of visceral metastases, Karnofsky performance score, primary tumor type, presence of a complete pathological fracture and preoperative hemoglobin content. Multivariate regression analysis showed that pathological fracture, visceral metastases, haemoglobin content < 7 mmol/L and lung cancer were negative prognostic factors for survival. Myeloma was the sole positive prognostic factor for survival.

Microcirculation plays a crucial role in physiological processes of tissue oxygenation and nutritional exchange. Measurement of microcirculation can be applied on many organs in various pathologies. In this paper we aim to review the technique of non-invasive methods for imaging of the microcirculation. Methods covered are: videomicroscopy techniques, laser Doppler perfusion imaging, and laser speckle contrast imaging. Videomicroscopy techniques, such as orthogonal polarization spectral imaging and sidestream dark-field imaging, provide a plentitude of information and offer direct visualization of the microcirculation but have the major drawback that they may give pressure artifacts. Both laser Doppler perfusion imaging and laser speckle contrast imaging allow non-contact measurements but have the disadvantage of their sensitivity to motion artifacts and that they are confined to relative measurement comparisons. Ideal would be a non-contact videomicroscopy method with fully automatic analysis software.

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IntroductionMobility is not evenly distributed between and within societies (Hall, 2005). Measured in travel distances, people living in industrialized countries are far more mobile on an averaged per capita basis than those in developing countries (Gilbert and Perl, 2008;Scha« fer and Victor, 2000). However, recent research indicates that the greatest differences in mobility may actually be found within countries, as a minor share of highly mobile travellers seems to account for a major share of the distances travelled within any given country (Go« ssling et al, 2009a). While increasingly mobile lifestyles are usually associated with changing economic, cultural, social, and political relations (

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Skeletal muscle mass decreases during neoadjuvant chemotherapy. Skeletal muscle loss during neoadjuvant chemotherapy impairs the conditions for adjuvant chemotherapy.

During the latest decade, a renaissance of bicycling in urban transportation has occurred in many Western European cities. This opens up for a development of bicycle tourism as a form of urban sustainable tourism, taking advantage of improved infrastructure and facilities for cycling tourists. The aim of this study is to conceptualise the dynamics behind the development of urban bicycle tourism. This development may be viewed as an innovative process based on incremental changes in local socio-technological mobility systems. An analytical framework is proposed, based on the following categories: urban planning, bicycle tourism services, communication, and place making. In the analysis, evidence from the Greater Copenhagen region is used to contextualise particularly these perspectives of the development of urban bicycle tourism. In each of the four categories, evidence of innovative services or procedures supporting bicycle tourism was found. However, the most important source of incremental innovation is likely to be found on a systemic level, between the actors in the destination. It is also argued that the development of urban bicycle tourism is highly path dependent, related to the local bicycle culture. Bicycle tourism should not be viewed as isolated from the locals' everyday cycling.