The ANTAREX 1 project aims at expressing the application selfadaptivity through a Domain Specific Language (DSL) and to runtime manage and autotune applications for green and heterogeneous High Performance Computing (HPC) systems up to Exascale. The DSL approach allows the definition of energy-efficiency, performance, and adaptivity strategies as well as their enforcement at runtime through application autotuning and resource and power management. We show through a mini-app extracted from one of the project application use cases some initial exploration of application precision tuning by means enabled by the DSL.
Artificial intelligence (AI) is undergoing a revolution thanks to the breakthroughs of machine learning algorithms in computer vision, speech recognition, natural language processing and generative modelling. Recent works on publicly available pharmaceutical data showed that AI methods are highly promising for Drug Target prediction. However, the quality of public data might be different than that of industry data due to different labs reporting measurements, different measurement techniques, fewer samples and less diverse and specialized assays. As part of a European funded project (ExCAPE), that brought together expertise from pharmaceutical industry, machine learning, and high-performance computing, we investigated how well machine learning models obtained from public data can be transferred to internal pharmaceutical industry data. Our results show that machine learning models trained on public data can indeed maintain their predictive power to a large degree when applied to industry data. Moreover, we observed that deep learning derived machine learning models outperformed comparable models, which were trained by other machine learning algorithms, when applied to internal pharmaceutical company datasets. To our knowledge, this is the first large-scale study evaluating the potential of machine learning and especially deep learning directly at the level of industry-scale settings and moreover investigating the transferability of publicly learned target prediction models towards industrial bioactivity prediction pipelines.
Part 6: AlgorithmsInternational audienceComputational performance of route planning algorithms has become increasingly important in recent real navigation applications with many simultaneous route requests. Navigation applications should recommend routes as quickly as possible and preferably with some added value. This paper presents a performance evaluation of the main part of probabilistic time-dependent route planning algorithm. The main part of the algorithm computes the full probability distribution of travel time on routes with Monte Carlo simulation. Experiments show the performance of the algorithm and suggest real possibilities of use in modern navigation applications
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