Background: Odorant-binding proteins mediate recognition of odors that guide mosquito behavior. Results: Studies of AgamOBP1 reveal the binding site for the natural repellent 6-methyl-5-hepten-2-one (6-MH). Conclusion: 6-MH binds to the same site as DEET and blocks the interaction of AgamOBP1 with other OBPs. Significance: In targeting OBPs in mosquitoes, the location of repellent binding may count more than the binding affinity.
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