Fifty‐three patients with symptoms suggestive of S.L.E. were studied clinically and serologically (antinuclear reactions included complement fixation against nucleoprotein, DNA, and histone, tests for rheumatoid arthritis). Clinically and serologically, the patients with (72 per cent) and without (18 per cent) L.E. cell phenomenon did not differ significantly and seem to represent one nosological entity. It is suggested that in the past too much emphasis has been placed on a positive L.E. cell test in establishing the diagnosis of S.L.E. The results clearly indicate that in addition to this test, antinuclear reactions are an indispensable tool in establishing the diagnosis of S.L.E.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.