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There have been few comprehensive analyses of register variation conducted in a European language other than English. Spanish provides an ideal test case for such a study: Spanish is a major international language with a long social history of literacy, and it is a Romance language, with interesting linguistic similarities to, and differences from, English. The present study uses Multi-Dimensional (MD) analysis to investigate the distribution of a large set of linguistic features in a wide range of spoken and written registers: 146 linguistic features in a twenty-million words corpus taken from nineteen spoken and written registers. Six primary dimensions of variation are identified and interpreted in linguistic and functional terms. Some of these dimensions are specialised, without obvious counterparts in the MD analyses of other languages (e.g., a dimension related to discourse with a counterfactual focus). However, other Spanish dimensions correspond closely to dimensions identified for other languages, reflecting functional considerations such as interactiveness, personal stance, informational density, argumentation, and a narrative focus.

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Understanding the influence of exposure of biological systems to THz radiation is becoming increasingly important. There is some evidence to suggest that THz radiation can influence important activities within mammalian cells. This study evaluated the influence of the high peak power, low average power THz radiation produced by the ALICE (Daresbury Laboratory, UK) synchrotron source on human epithelial and embryonic stem cells. The cells were maintained under standard tissue culture conditions, during which the THz radiation was delivered directly into the incubator for various exposure times. The influence of the THz radiation on cell morphology, attachment, proliferation and differentiation was evaluated. The study demonstrated that there was no difference in any of these parameters between irradiated and control cell cultures. It is suggested that under these conditions the cells are capable of compensating for any effects caused by exposure to THz radiation with the peak powers levels employed in these studies.

This paper presents the first plasmid DNA irradiations carried out with Very High Energy Electrons (VHEE) over 100–200 MeV at the CLEAR user facility at CERN to determine the Relative Biological Effectiveness (RBE) of VHEE. DNA damage yields were measured in dry and aqueous environments to determine that ~ 99% of total DNA breaks were caused by indirect effects, consistent with other published measurements for protons and photons. Double-Strand Break (DSB) yield was used as the biological endpoint for RBE calculation, with values found to be consistent with established radiotherapy modalities. Similarities in physical damage between VHEE and conventional modalities gives confidence that biological effects of VHEE will also be similar—key for clinical implementation. Damage yields were used as a baseline for track structure simulations of VHEE plasmid irradiation using GEANT4-DNA. Current models for DSB yield have shown reasonable agreement with experimental values. The growing interest in FLASH radiotherapy motivated a study into DSB yield variation with dose rate following VHEE irradiation. No significant variations were observed between conventional and FLASH dose rate irradiations, indicating that no FLASH effect is seen under these conditions.

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