When looking at a scene, observers feel that they see its entire structure in great detail and can immediately notice any changes in it However, when brief blank fields are placed between alternating displays of an original and a modified scene, a striking failure of perception is induced Identification of changes becomes extremely difficult, even when changes are large and made repeatedly Identification is much faster when a verbal cue is provided showing that poor visibility is not the cause of this difficulty Identification is also faster for objects considered to be important in the scene These results support the idea that observers never form a complete, detailed representation of their surroundings In addition, the results indicate that attention is required to perceive change, and that in the absence of localized motion signals attention is guided on the basis of high-level interest
Microsaccades, or tiny eye movements that take place during periods of fixation, have long been thought to be random artifacts of the oculomotor system. Here we demonstrate a possible link between microsaccades and covert attention shifts. We designed two psychophysical tasks involving spatial cues that had identical sensory stimuli but differing patterns of attentional benefits and costs. We found that microsaccades, rather than being randomly distributed, had directions that were directly correlated with the directions of covert attention shifts in the two tasks. Our results suggest that microsaccades occur because of subliminal activation of the oculomotor system by covert attention.
This study examined the relationship between three variables, compassion fatigue (CF), compassion satisfaction (CS), and burnout, and provider and setting characteristics in a sample of 1,121 mental health providers in a rural southern state. Respondents completed the Professional Quality of Life Scale as part of a larger survey of provider practice patterns. Female gender was associated with higher levels of CF, and therapists with specialized training in trauma work reported higher levels of CS than nonspecialists. Provider discipline proved to be an important factor, with psychiatrists reporting higher levels of CF than their non-medical counterparts. When providers were compared using rural, urban, and rural with urban influence classifications, the most rural providers reported increased levels of burnout but could not be distinguished from their colleagues on the CF and CS subscales. Important practice, education, and policy implications are noted for a multidisciplinary audience. American author James Baldwin (1963) wrote, ''One can give nothing whatever without giving oneself, that is to say risking oneself'' (p. 100). Risking exposure to vicarious trauma is an inherent part of the process when working with traumatized persons. The empirical literature has documented mental health consequences of professionals' exposure to trauma patients, responses that differ depending upon individual and contextual characteristics specific to the provider and the practice setting. This study explores variables that might influence such responses to vicarious exposure to traumatic stress by examining compassion fatigue (CF), compassion
1957-Data fusion for sensory information processing systems / James J. Clark, Alan L. Yuille. p. cm. -Kluwer international series in engineering and computer science ; SECS 105) Includes bibliographical references (p. ) and index. ISBN 978-1-4419-5126-7 ISBN 978-1-4757-2076-1 (eBook)
When brief blank fields are placed between alternating displays of an original and a modified scene, a striking failure of perception is induced: The changes become extremely difficult to notice, even when they are large, presented repeatedly, and the observer expects them to occur (Rensink, O'Regan, & Clark, 1997). To determine the mechanisms behind this induced "change blindness", four experiments examine its dependence on initial preview and on the nature of the interruptions used. Results support the proposal that representations at the early stages of visual processing are inherently volatile, and that focused attention is needed to stabilize them sufficiently to support the perception of change.Over the past few decades, evidence has been accumulating that-contrary to our subjective impressions-we do not have a coherent and detailed representation of the coherent and detailed world that surrounds us. For example,
Circulating tumor DNA (ctDNA) analysis is being incorporated into cancer care; notably in profiling patients to guide treatment decisions. Responses to targeted therapies have been observed in patients with actionable mutations detected in plasma DNA at variant allele fractions (VAFs) below 0.5%. Highly sensitive methods are therefore required for optimal clinical use. To enable objective assessment of assay performance, detailed analytical validation is required. We developed the InVisionFirst™ assay, an assay based on enhanced tagged amplicon sequencing (eTAm-Seq™) technology to profile 36 genes commonly mutated in non-small cell lung cancer (NSCLC) and other cancer types for actionable genomic alterations in cell-free DNA. The assay has been developed to detect point mutations, indels, amplifications and gene fusions that commonly occur in NSCLC. For analytical validation, two 10mL blood tubes were collected from NSCLC patients and healthy volunteer donors. In addition, contrived samples were used to represent a wide spectrum of genetic aberrations and VAFs. Samples were analyzed by multiple operators, at different times and using different reagent Lots. Results were compared with digital PCR (dPCR). The InVisionFirst assay demonstrated an excellent limit of detection, with 99.48% sensitivity for SNVs present at VAF range 0.25%-0.33%, 92.46% sensitivity for indels at 0.25% VAF and a high rate of detection at lower frequencies while retaining high specificity (99.9997% per base). The assay also detected ALK and ROS1 gene fusions, and DNA amplifications in ERBB2, FGFR1, MET and EGFR with high sensitivity and specificity. Comparison between the InVisionFirst assay and dPCR in a series of cancer patients showed high concordance. This analytical validation demonstrated that the InVisionFirst assay is highly sensitive, specific and robust, and meets analytical requirements for clinical applications.
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