This large series of PRES cases shows that atypical distributions and imaging manifestations of PRES have a higher incidence than commonly perceived, and atypical manifestations do not correlate well with the edema severity.
A 35-year-old woman presented with neurotoxicity correlated to an i.v. regimen of 5-fluorouracil as episodes of acute confusional state and abnormalities of symmetrically restricted diffusion in the periventricular white matter and corpus callosum. On discontinuing the medication, the areas of severely restricted diffusion had entirely resolved, with minimal residual T2 signal abnormality. In this case, immediate discontinuation of the chemotherapeutic agent apparently reversed the patient's symptoms and findings on MRI. The scant information available in the published literature regarding this phenomenon is reviewed with regard to 5-fluorouracil.
Adamantane-l-carboxaldehyde.-N-Methyl-N-phenyladamantane-l-carboxamide (32 g., 0.082 mole) was dissolved in 100 ml. of dry, redistilled tetrahydrofuran. The stirred solution was maintained at 0-5°with an ice bath. A slurry of 1.03 g. (0.027
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