Computed tomographic (CT) enterography combines the improved spatial and temporal resolution of multi-detector row CT with large volumes of ingested neutral enteric contrast material to permit visualization of the small bowel wall and lumen. Adequate luminal distention can usually be achieved with oral hyperhydration, thereby obviating nasoenteric intubation and making CT enterography a useful, well-tolerated study for the evaluation of diseases affecting the mucosa and bowel wall. Unlike routine CT, which has been used to detect the extraenteric complications of Crohn disease such as fistula and abscess, CT enterography clearly depicts the small bowel inflammation associated with Crohn disease by displaying mural hyperenhancement, stratification, and thickening; engorged vasa recta; and perienteric inflammatory changes. As a result, CT enterography is becoming the first-line modality for the evaluation of suspected inflammatory bowel disease. CT enterography has also become an important alternative to traditional fluoroscopy in the assessment of other small bowel disorders such as celiac sprue and small bowel neoplasms.
MR enterography and CT enterography have similar sensitivities for detecting active small-bowel inflammation, but image quality across the study cohort was better with CT. Cross-sectional enterography provides complementary information to ileocolonoscopy.
At enteric phase CT enterography, jejunal attenuation is greater than ileal attenuation and collapsed bowel loops demonstrate greater attenuation than distended bowel loops. Mural hyperenhancement and increased mural thickness are the most sensitive CT findings of active Crohn disease.
In this referral population, the sensitivity of CT enterography for detecting small bowel bleeding sources and small bowel masses was significantly greater than that of capsule endoscopy. On the basis of these findings, the addition of multiphase CT enterography to the routine diagnostic work-up of patients with OGIB should be considered, particularly in patients with negative findings at capsule endoscopy.
This retrospective HIPAA-compliant study was approved by the institutional review board and institutional conflict of interest committee. Patients gave informed consent for use of medical records. The purpose of the study was to retrospectively evaluate the findings depicted at computed tomographic (CT) enterography performed with a 64-section CT system and by using neutral enteric contrast material and a three-phase acquisition in patients with obscure gastrointestinal bleeding (OGIB). Twenty-two outpatients (11 men, 11 women; age range, 37-83 years) with OGIB underwent CT enterography. Findings were compared with capsule and traditional endoscopic, surgical, and angiographic findings. CT enterographic findings were positive for a bleeding source in 10 (45%) of 22 patients. Eight of 10 positive findings at CT enterography were also positive at capsule endoscopy or subsequent clinical diagnosis. CT enterography helped correctly identify three lesions undetected at capsule endoscopy. Study results suggest that multiphase, multiplanar CT enterography may have a role in the evaluation of OGIB.
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