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when inactive, denatured, virus RNA is incorporated into a reconstituted nucleoprotein. It should be emphasized that the present data do not, in our opinion, permit a choice between the foregoing alternative explanations. The possibility that small amounts of otherwise inactive virus RNA components may, when incorporated into DNA-bearing nucleoproteins, render the polymer infectious is subject to experimental verification. The same is true of the alternative proposal that TMV protein may induce some biological activity in an indifferent nucleic acid incorporated into a reconstituted nucleoprotein. It is hoped that such investigations will permit an unequivocal explanation of the results just described. We wish to thank Mrs. Katherine Baker, Mrs. Ellen E. Richman, and Mrs. Georgia B. Shearer for assistance in carrying out these experiments.

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