SummaryThe case records of 23 horses and one donkey affected by hypertrophic osteopathy (HO) (Marie's disease) were reviewed. All affected animals presented with limb swellings, which were bilaterally symmetrical and usually involved both fore-and hindlimbs. Associated signs included stiffnesdlameness and weight loss. Radiological features included perlosteal new bone formation over the diaphyses and metaphyses of affected bones. The metacarpal and metatarsal bones were most frequently affected. Articular surfaces remained free of disease. Seventeen animals were destroyed on humane grounds, 3 horses recovered after successful treatment of the primary disease, 3 horses recovered after symptomatic treatment and one horse was lost to follow-up. Significant primary diseases that were believed to predispose to HO were identified @re-or post mortem) in 14 cases.

Neonatal mouse hearts fully regenerate after ventricular resection similar to adult zebrafish. We established cryoinjury models to determine if different types and varying degrees of severity in cardiac injuries trigger different responses in neonatal mouse hearts. In contrast to ventricular resection, neonatal mouse hearts fail to regenerate and show severe impairment of cardiac function post transmural cryoinjury. However, neonatal hearts fully recover after non-transmural cryoinjury. Interestingly, cardiomyocyte proliferation does not significantly increase in neonatal mouse hearts after cryoinjuries. Epicardial activation and new coronary vessel formation occur after cryoinjury. The profibrotic marker PAI-1 is highly expressed after transmural but not non-transmural cryoinjuries, which may contribute to the differential scarring. Our results suggest that regenerative medicine strategies for heart injuries should vary depending on the nature of the injury.

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SUMMARY An 8‐month old Welsh Cob filly had shown progressive ataxia of the hindquarters since about 3 months of age. Autopsy revealed a venous malformation resulting in malacia in the ninth thoracic segment of the spinal cord. It is proposed that the tissue destruction associated with this congenital lesion gave rise to the ataxia. RÉSUMÉ Une pouliche Cob Welsh agée de huit mois montrait depuis l'âge de trois mois des signes d'une ataxie progressive postérieure. L'autopsie mit en évidence une malformation veineuse avec dégénérescence du 9è segment thoracique de la moelle épinière. On pense qu'il en résulta l'ataxie constatée. ZUSAMMENFASSUNG Bei einem 8 Monate alten Welsh Cob Stutfohlen wurde eine seit 5 Monaten bestehende, progressive Ataxie der Nachhand beobachtet. Die Autopsie zeigte eine Venenmissbildung mit resultierender Malazie im 9. Thorakalsegment des Rückenmarks. Es wird vermutet, dass die Gewebszerstörung auf diese kongenitale Missbildung zurückzuführen ist und Anlass zu Ataxie gegeben hat.