Chungkookjang (fermented soybeans) contains diverse peptides. Human breast cancer MDA-MB-231 cells were treated with peptide H derived from Chungkookjang, and TNFα expression in the cells was conspicuously repressed, suggesting peptide H's regulation of IL6 since IL6 is induced by TNFα. The structure of peptide H was different from those of glucocorticoid and dexamethasone, suggesting different mechanisms of TNFα expression suppression. Peptide H which reduces TNFα expression can be developed as drugs for cancer, rheumatoid arthritis and Crohn's disease, after more investigation.
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