Conflict of interest: Conflict of interest statement: JWK discovered tafamidis at the Scripps Research Institute; is a shareholder of FoldRx (Pfizer), the companies that developed tafamidis into a drug; and he and ETP receive royalty payments from tafamidis sales. JWK is a paid consultant for the Pfizer Orphan and Rare Diseases organization. Pfizer supported JWK's expenses with travel and accommodation for scientific meetings. TC is a past and current investigator in clinical trials sponsored by FoldRx, Pfizer, Alnylam, Ionis, and Prothena; these trials were paid per protocol to Centro Hospitalar do Porto. TC is a consultant for Pfizer, Alnylam, Ionis, and Prothena. TC has spoken on behalf of Pfizer, Alnylam, Glaxo, and Prothena at scientific meetings and received financial compensation. Pfizer, Alnylam, Ionis, and Biogen supported TC's expenses with travel, accommodation, and registration for scientific meetings.