Purpose: We aimed to describe the outcomes, focusing on the hearing and neurological development, of children born to mothers with SARS-CoV-2 infection during pregnancy, and to evaluate the persistence of maternal antibodies in the rst months of life.Methods:An observational, prospective study at a tertiary hospital in Madrid (Spain) on infants born to mothers infected with SARS CoV-2 during pregnancy between March and September 2020. A follow-up visit at 1-3 months of age with a physical and neurological examination, cranial ultrasound (cUS), SARS-CoV-2 RT-PCR on NPS and SARS-CoV-2 serology were performed. Hearing was evaluated at birth through the automated auditory brainstem response and at six months of age through the auditory steady-state response. A neurodevelopmental examination using the Bayley-III scale was performed at 12 months of age.Results:Of 95 infants studied, neurological examination was normal in all of them at the follow-up visit, as was the cUS in 81/85 (95%) infants, with only mild abnormalities in four of them. Serology was positive in 47/95 (50%) infants, which was not associated with symptoms or severity of maternal infection. No hearing loss was detected and neurodevelopment was normal in 96% of the children (median Z score: 0). Conclusions: In this cohort, the majority of infants born to mothers with SARS-CoV-2 infection during pregnancy were healthy children with a normal cUS, no hearing loss and normal neurodevelopment in the rst year of life. Only half of the infants had a positive serological result during the follow-up.
What Is KnownHearing loss and neurodevelopmental delay in infants born to mothers with SARS-CoV-2 infection during pregnancy has been suggested, although data is inconsistent. Maternal antibody transfer seems to be high, with a rapid decrease during the rst weeks of life.What is new: Most infants born to mothers with SARS-CoV-2 infection during pregnancy had normal hearing screening, cranial ultrasound and neurodevelopmental status at 12 months of life. Antibodies against SARS-CoV-2 were only detected in 50% of the infants at two months of life.Here we set out to describe the clinical outcomes of children born to mothers who were infected with SARS-CoV-2 during pregnancy, focusing particularly on the hearing and neurological development of the infants, and evaluating the persistence of maternal antibodies in these children in the rst months of life.
MethodsWe carried out an observational prospective study at the Hospital Universitario 12 de Octubre, a tertiarycare center located in southern Madrid (Spain). This hospital covers an estimated population of 400,000 inhabitants and attends around 4,000 deliveries each year. Infants born from March to September 2020 to mothers with SARS-CoV-2 infection during pregnancy were included in this study.Mothers were considered to have had a SARS-CoV-2 infection during pregnancy if they had either a positive result in a SARS-CoV-2 Reverse-Transcription Polymerase Chain Reaction (RT-PCR) on a nasopharyngeal swab (NPS) sample and/o...
Purpose: We aimed to describe the outcomes, focusing on the hearing and neurological development, of children born to mothers with SARS-CoV-2 infection during pregnancy, and to evaluate the persistence of maternal antibodies in the first months of life.
Methods:An observational, prospective study at a tertiary hospital in Madrid (Spain) on infants born to mothers infected with SARS CoV-2 during pregnancy between March and September 2020. A follow-up visit at 1-3 months of age with a physical and neurological examination, cranial ultrasound (cUS), SARS-CoV-2 RT-PCR on NPS and SARS-CoV-2 serology were performed. Hearing was evaluated at birth through the automated auditory brainstem response and at six months of age through the auditory steady-state response. A neurodevelopmental examination using the Bayley-III scale was performed at 12 months of age.
Results:Of 95 infants studied, neurological examination was normal in all of them at the follow-up visit, as was the cUS in 81/85 (95%) infants, with only mild abnormalities in four of them. Serology was positive in 47/95 (50%) infants, which was not associated with symptoms or severity of maternal infection. No hearing loss was detected and neurodevelopment was normal in 96% of the children (median Z score: 0).
Conclusions: In this cohort, the majority of infants born to mothers with SARS-CoV-2 infection during pregnancy were healthy children with a normal cUS, no hearing loss and normal neurodevelopment in the first year of life. Only half of the infants had a positive serological result during the follow-up.
Introducción: el virus respiratorio sincitial (VRS) es una de las principales causas de infección respiratoria en niños, con una importante morbimortalidad en menores de cinco años, siendo la segunda causa global de muerte entre las infecciones de vías respiratorias inferiores. El VRS se clasifica en dos subtipos según las diferencias antigénicas y suelen circular de forma concurrente. Tradicionalmente, se creía que el subtipo A causaba una infección más grave, aunque trabajos recientes han demostrado resultados contradictorios. Es un virus estacionario cuya temporada epidémica se produce en España entre diciembre y marzo. Objetivo: el objetivo del estudio es describir y comparar las temporadas
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