Since the original discovery of Weinreb [1], that N-methoxy-N-methyl amides 1, now popularly called as Weinreb amides (WA), cleanly reacted with Grignard reagents and organolithium to produce ketones, these amides have gained wide importance as very effective acylating agents for various organometallic reagents The esters and lactones have been invariably converted [5a -g] to Weinreb amides (Scheme 2) by using a combination of trimethyl aluminium and
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Di-O-isopropylidene sugar derivatives (1a-9a) on treatment with a solution of Zn(NO 3 ) 2 ∑6H 2 O in acetonitrile, undergo regioselective hydrolysis to furnish the corresponding diols (1b-9b) in excellent yields.
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