Combine Pegylated interferon therapy and ribavirin is most commonly usedtreatment in chronic hepatitis C patients. Along with other complications, different psychiatricdisorders are observed during combination therapy including depression. Depression is themajor morbidity as it may lead to different destructive ideation including suicide among patientson treatment. We have tried to calculate the frequency of depression along with associatedfactors in our present study. Objectives: To find out the frequency of depression duringPegylated interferon therapy for chronic hepatitis C. Study Design: Descriptive study. Setting:Liaquat University of Medical & Health Sciences, Jamshoro / Hyderabad Duration: The durationof study was six months starting from 01-01-2014 to 31-06-2014. Methodology: Two hundredand fifty two cases of chronic hepatitis C on the basis of anti HCV (ELISA) and PCR positivewere selected in this study. Results: Out of 252 patients, 111 (44%) were males and 141(56%)were females. Most of the patients belonged to 26 to 50 years of age. The duration of treatmentwas 12 weeks. Two hundred & eight (82.5%) patients had ever married while the remaining17.5% were unmarried. Out of 106 (42%) depressed patients, 39 (37%) had mild, 31 (29%) hadmoderate, 20 (19%) had moderately severe and 15 (15%) had severe depression. Conclusion:It was observed that depression is a common during combination therapy with Peg interferonand the ribavirin in chronic HCV patients.
Combine Pegylated interferon therapy and ribavirin is most commonly used treatment in chronic hepatitis C patients. Along with other complications, different psychiatric disorders are observed during combination therapy including depression. Depression is the major morbidity as it may lead to different destructive ideation including suicide among patients on treatment. We have tried to calculate the frequency of depression along with associated factors in our present study. Objectives: To find out the frequency of depression during Pegylated interferon therapy for chronic hepatitis C.
Objectives: To determine the serum lipid profile in patients with chronic HCVinfection and correlation between serum lipid levels and liver histology. Material and methods:Descriptive study was carried out in Medical Unit I of Liaquat University Hospital JamshoroHyderabad, from September 2007 to August 2009. Convenience sampling was used and 30patients were selected. Positive PCR test for HCV, non diabetic patients and non cirrhotic patientswere included in this study. All the patients were selected from the medical OPD. Clinicalexamination performed and then blood tests were done. Serum lipid profile were determined inall participants after an overnight fast of 12 h. TC, TG, and HDL-C was measured enzymaticallywith commercial kits (Olympus System Reagent, Hamburg, Germany) by the use of anautomated analyzer. The body mass index (BMI) was calculated in accordance with the formulaof weight (kg) divided by height2 (m2). Selected patients were called in the ward and biopsy wasdone via Trucut needle and the specimen was fixed in formalin. The biopsies were used tocalculate the degree of steatosis (0-3) and fibrosis by METAVIR score. Results: A total of 30patients were selected for this study. Out of these 19 were males and 11 females. The patientswere divided in three groups. Patients with chronic HCV infection were found to have significantlylower levels of serum TC, HDL-C and LDL-C than normal adults values. Steatosis was present insignificant number of patients (36.67%). However, steatosis was not correlating with fibrosis(p>0.005). Conclusions: Hypolipoproteinemia and steatosis are important factors which areassociated with chronic hepatitis C
ABSTRACT… Objectives: To find out the frequency of hypoglycemia in patients with diabetic nephropathy. Study Design: Cross sectional study. Setting: Emergency department and department of medicine Liaquat university Hospital Hyd/ Jamshoro. Study Period: One year from 01-03-2009 to 28-02-2010. Methodology: Two hundred cases of diabetic nephropathy on the basis of symptoms and signs of hypoglycemia were selected in this study. Results: Out of 200 patients, 102(51%) were males and 98(49%) were females, 10.5% had type-1 diabetes and 89.5% had type-2 diabetes. Most of the patients belonged to 60 to 75 years of age. The average duration of diabetes was 12.20 ± 6.14 years. Out of 23 hypoglycemic patients, 5 (21.7%) had type-1 diabetes in which 4 were male and one was female while 18 (78.3%) had type-2 diabetes in which 10 were male and 8 were female patients. Conclusion: It was observed that hypoglycemia was common in diabetic patients, who developed renal failure due to diabetic nephropathy. Key words:Diabetes mellitus, Nephropathy, Renal failure, Hypoglycemic Article Citation: Liaquat J, Bawany MA, Shaikh N, Khahro AA, Naz F. Diabetic nephropathy; to find out the frequency of hypoglycemia in these patients. Professional Med J 2016;23(2):121-128.
Introduction: Hepatic encephalopathy is a common and serious complication affecting patients with liver disease. Helicobacterpylori bacterium is postulated to be involved in worsening of this condition via its potential to create ammonia within the gastrointestinal tract.Objective: The objective of this study was to determine the frequency of H pylori infection in cirrhotic patients who were suffering from hepaticencephalopathy. Design: Case series study. Setting: Medical Unit-IV of Liaquat University Hospital, Hyderabad. Period: January to July 2010.Methodology: Methodology: Every confirmed case of cirrhosis of liver who presented with acute confusional state, and loss of consciousnessto the emergency department of hospital was considered for enrollment in the study. The presence of hepatic encephalopathy was confirmedand its severity grading was done clinically. Subsequently H pylori serological tests were done on every patient and a cut off value of 200:1antibody titer was considered as positive. Primary outcome variable was presence or absence of H pylori antibody titer. Results: A total of 115patients were selected, 69 (60%) were males and 46 (40%) were females. The mean age of patients was 49.36 years with a SD of 7.8. Antibodyto H pylori was present in 83 (72.17%) patients, whereas it was absent in 32 (27.83%). Two out of ten patients (20%) who were in Grade I hepaticencephalopathy showed a positive test for H pylori antibody. In Grade II hepatic encephalopathy 17 out of 19 patients (89.47%) were havingpositive H pylori antibody, in grade III 29 out of 34 (85.29%) and grade IV 35 out of 52 patients (67.3%) were having the antibody to H pylori.Conclusions: Further studies are warranted to evaluate the arguments for and against the role of H pylori in the pathogenesis of hepaticencephalopathy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.