SummaryThe partition coefficients (P) of some synthesized cyanopyridine and chalcone compounds have been studied in 1-octanol-water system at different pH. It is observed that log P depends on pH and nature of substitution group present in the compounds. The central moiety also play important role to affect hydrophilic/ hydrophobic nature of compounds. There is no regular trend for the variation of log P with different pH.Key words: partition coefficient, cyanopyridines, chalcones, 1-octanol-water system.
ResumenCoeficientes de reparto 1-octanol-agua de algunos compuestos derivados de cianopiridina y chalconaLos coeficientes de reparto (P) de algunos compuestos sintetizados derivados de cianopiridina y chalcona se estudiaron en el sistema 1-octanol-agua a diferentes valores de pH. Se observa que log P depende del pH y de la naturaleza del grupo sustituyente presente en los compuestos. El grupo central también desempeña un papel importante en la naturaleza hidrofílica/hidrofóbica de los compuestos. No hay una tendencia regular para la variación de log P con el pH.Palabras clave: coeficiente de reparto, cianopiridinas, chalconas, sistema 1-octanolagua.
<p>Some new cyanopyridine derivatives have been synthesized and their characterization was done by IR, 1H NMR and mass spectral data. Further, some physicochemical properties such as density, refractive index, conductance etc. have been studied for these synthesized compounds, in different solvents at 308.15 K.</p>
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