The COVID-19 pandemic introduced unprecedented challenges for individuals in organizations to maintain their interpersonal connections, which are critical for resource exchange. Because prior research has focused on how networks gradually evolve over time, there is little insight into how an exogenous shock, such as the pandemic, would reshape informal ties among colleagues that comprise their social networks. Drawing upon the optimal matching theory of social support, we develop a psychological perspective on how individuals recalibrate their social ties to enable coping with the uncertainty and anxiety introduced by the pandemic shock. We test our theory using a three-wave network data set from a sample of colocated, fulltime MBA students before and after the onset of the pandemic. Following the onset of the pandemic, we found there was an overall reduction in the maintenance of advice ties. We also found that emotional exhaustion exacerbated this effect, and when emotional exhaustion was high, racially homophilous advice ties were just as likely to be dropped as heterophilous advice ties. We also found, unexpectedly, that COVID-19 reduced the maintenance of friendship ties, perhaps because social distancing reduced emotional support opportunities. Thoughts of anticipated inclusion mitigated this negative effect, particularly for racially heterophilous friendships. Individuals in organizations have psychological agency for reordering their social networks to respond to demands created by existential crises.
The purpose of this study was to understand the changes of metabolic pathway induced by alpha-melanocyte-stimulating hormone (α-MSH) in B16F10 melanoma cells in an untargeted metabolomics approach. Cells were treated with 100 nM of α-MSH and then incubated for 48 h. α-MSH increased tyrosinase activity and melanin content by 56.5 and 61.7%, respectively, compared to untreated cells after 48 h of cultivation. The clear separation between groups was observed in the principal component analysis score plot, indicating that the levels of metabolites of melanoma cells were altered by treatment with α-MSH. Metabolic pathways affected by α-MSH were involved in some amino acid metabolisms. The increased levels of fumaric acid, malic acid, oxaloacetic acid and citric acid related to the citric acid cycle pathway after α-MSH treatment suggested enhanced energy metabolism. Metabolic pathways altered by α-MSH treatment can provide useful information to develop new skin pigmentation inhibitors or anti-obesity drugs.
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