In the syntheses developed to access naturally occurring compounds, especially bioactive substances, boron-functionalized dienes (also "linchpin" reagents) are used as key reagents. Structurally unique dienes are found in nature, and play important biological and chemical roles. Recently, linchpin moieties have been proved as useful substrates for a variety of highly functionalized chemical transformations. The products of these processes are potentially of some use for the syntheses of an important class of natural products showing a wide range of biological activities. This review describes progress in the synthesis of borylsubstituted buta-1,3-dienes as well as their application in organic chemistry.
High-resolution
diffraction data have been used for modeling the
electron density distribution in the crystal structure of 4-[[4-(methoxy)-3-quinolinyl]thio]-3-thiomethylquinoline.
The results confirm the presence of intermolecular, electron pairs−σ-holes
S···S bonding. The calculated minimum energy distance
is 3.33–3.34 Å and agrees very well with the separation
of 3.3300(11) Å, observed in the crystal structure. A large spectrum
of weak interactions, including C–H···O, C–H···S,
and π···π has been analyzed by means of
electron density distribution details and Atoms-In-Molecules approach.
There is apparently a good agreement between the results obtained
with the multipolar Hansen-Coppens model and theoretical study. At
the same time, comparison with the results of the best independent
atom model has revealed its deficiencies.
Abstract:We report a new one-pot, iridium(I)-catalyzed direct method for the synthesis of alkynyl-substituted germanium compounds with various functional groups from commercially available reagents. More than 25 compounds were obtained and spectroscopically characterized. Moreover, detailed DFT cal-
A new route for the synthesis of functionalized alkenylsilatranes has been developed based on ruthenium-catalyzed trans-silylation with olefins. This transformation allowed for the synthesis of new (E)-alkenylsilatranes in good yields and excellent selectivity. Experimental studies concerning the reaction mechanism were carried out and the intermediate ruthenium-silatranyl complex was isolated and characterized. Moreover, detailed DFT calculations regarding the mechanism of the silylative coupling catalytic cycle of silatranes catalyzed by [Ru]-H complexes were also performed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.