Liver transplantation has had a major impact on survival of patients with FHF, most significantly in patients with FHF due to causes other than paracetamol poisoning, in whom survival without transplantation is uncommon. Survival in those who undergo transplantation for FHF is excellent, but a significant percentage of patients listed for transplantation die before a donor organ becomes available.
Summary
Flucloxacillin is a commonly prescribed semisynthetic penicillinase‐resistant penicillin primarily used for the treatment of cutaneous staphylococcal infections. It is well‐recognized that flucloxacillin may occasionally result in fatal hepatic injury. We report the case of a 40‐year‐old woman who developed fulminant hepatic failure and aplastic anaemia following a course of oral flucloxacillin. At the time of transplantation the patient was severely neutropenic. Post‐transplant, the patient received single donor leucocyte transfusions, which resulted in a dramatic increase in neutrophil count. The patient was discharged from hospital after 120 days with normal liver function and recovered bone marrow. In this report, we discuss the care of patients with aplastic anaemia in the peritransplant setting.
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