on behalf of the Italian Network for Laminopathies (NIL) † Background: Mutations in the LMNA (lamin A/C) gene have been associated with neuromuscular and cardiac manifestations, but the clinical implications of these signs are not well understood.Objective: To learn more about the natural history of LMNArelated disease.
With long-term follow-up, LAV at MRI represents the main determinant of outcome after PVI plus linear lesion for ablation of paroxysmal and persistent atrial fibrillation.
The use of cardiac implantable electronic devices (CIED) increased over time, followed by rise of CIED-related complications, mainly infections and malfunctions. A clear diagnosis of CIED infection is of pivotal importance. When infection is confirmed, transvenous lead extraction (TLE) becomes mandatory, with associated risks and mortality. Local lesions at the device pocket often return negative swabs and tissue specimens, but conservative interventions are inconclusive, raising risks of systemic dissemination of infection and difficulties of subsequent TLE any more. When local bacteriological analyses are positive, once again, a contamination effect cannot be excluded. So traditional local swabs and tissue specimens exhibit low sensitivity and specificity for diagnosis of CIED infection. On the contrary, in cases sepsis, blood samples show high specificity, while the sensibility remains low, due to possible negative results in patients on antibiotics. In this scenario, the analysis of extracted device leads seems more appropriate for diagnostic purposes.
Radiofrequency catheter ablation is now the first line treatment for atrioventricular nodal reentrant tachycardia. The success rate is high with a low incidence of complications. However, a possible proarrhythmic effect of radiofrequency energy has been rarely reported and no study has demonstrated a direct correlation between the anatomic site of the radiofrequency application and the origin of a new post-ablation arrhythmia. We present a case of a focal atrial tachycardia that occurred after slow pathway radiofrequency catheter ablation for atrial nodal reentrant tachycardia and originating close to the previous ablation site. This tachycardia was successfully treated with a second ablation session.
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