The effects of isoproterenol on brown and white fat were studied by analyzing the total percentage lipid of the tissue and by the fluorescent histochemical method for catecholamines in sympathetic fibers. At dosages which were well below the LD50, isoproterenol selectively emptied brown fat without affecting the white fat at all. It was suggested that the rise in free fatty acids in the blood seen afer injection of isoproterenol is partly due to an emptying of brown fat.
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