1 report the results of a long-term, multicenter, randomized trial comparing fludarabine with chlorambucil in previously untreated patients with advanced chronic lymphocytic leukemia (CLL). In their study the treatments were repeated monthly for a maximum of 12 cycles unless patients had progressive disease, a complete remission, or a response that plateaued over two months of treatment. The hematologic toxicity of fludarabine is well established, and most prior studies have reported that fludarabine can be given for a maximum of six cycles. 2-5 In our experience, we have not been able to administer more than eight cycles of fludarabine therapy because of severe and prolonged myelosuppression. Rai et al. have not stated how many patients were able to receive 12 cycles of fludarabine, the median number of cycles of fludarabine administered, or the median number of courses of fludarabine needed to induce a complete remission.
Jackie Frankel, a fund raising coordinator for the Jaffa Institute, a Non‐Profit Organization in the Tel Aviv‐Jaffa area of Israel, offers this op‐ed piece in which she asserts that poverty, and not the Israeli/Palestinian conflict, is the greatest threat to Israel and calls on that country's government to make sweeping changes in order to supplant these concerns.
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