Our group has developed a ‘Step Up’ approach to the application of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in a rural trauma system. This incorporates viewing REBOA as a spectrum of technology. Examples of REBOA technology use to improve outcomes and provision of our system’s clinical practice guideline for the Step-Up application of REBOA technology in the care of trauma patients are presented.

Described is a single‐step synthesis of diazadioxacalix[4]arenes and diazadioxa[14]cyclophanes bearing an alternating N/O‐bridge substitution pattern. The macrocycles are formed regioselectively by condensation of 3‐ or 4‐aminophenols with 1,5‐difluoro‐2,4‐dinitrobenzene. Conformational properties of the macrocyclic products are discussed, as well as mechanistic details of the synthesis leading to the observed bridge‐pattern selectivity.

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