Six patients with chronic liver disease and six sex-, age (+/- 5 years)-, and weight (+/- 5 kg)-matched healthy control subjects received a single dose of two 100 mg tablets rimantadine HCl. Eight additional patients with chronic liver disease who were not matched to healthy subjects received a single dose of two 100 mg tablets of rimantadine HCl. Blood and urine samples were collected and rimantadine concentrations were determined by a GCMS method. The values for maximum plasma concentration, AUC, elimination half-life, and renal clearance were not significantly different between patients and control subjects, independent of the statistical analyses (parametric and nonparametric) used. The mean apparent elimination half-life, volume of distribution, and total clearance in the matched patients with liver disease were 32 hours, 24 L/kg, and 676 ml/min, respectively. Renal clearance and the amount excreted in the urine unchanged were 63 ml/min and 10%, respectively. In conclusion, rimantadine pharmacokinetics were not appreciably altered in patients with less severe chronic liver disease.
The application of Engineering With Nature® (EWN®) principles in urban environments and watersheds within and outside the US Army Corps of Engineers (USACE) is increasing. Extreme rainfall events have triggered the need and development of more sustainable urban infrastructure in urban areas such as New Orleans, Louisiana. This technical note documents a USACE–New Orleans District (MVN) project that successfully applied EWN principles in an urban landscape to reduce flood risk while providing other environmental, social, economic, and engineering benefits to both the community and the environment.
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