An apparatus is described for the partitioning of exhaled air into seven separate fractions beginning with the earliest portion of upper respiratory air and continuing to the terminal fraction of deep-lung air. The same volumetric fractions from successive exhalations are collected over a test period of any practical duration. This apparatus has been employed for the study of lung retention of inhaled particulate matter with particular reference to the separate estimate of upper respiratory retention and penetration to and deposition of particulate matter in alveolar spaces. The apparatus is employed with a mechanical respirator of the Drinker type, which fixes the respiratory pattern at any desired frequency and tidal volume.
A mechanical respirator with synchronized respiratory partitioning valve for guinea pigs is described. This apparatus is used for the separate determination of dust retention in the upper respiratory tract and deep lung spaces. The partitioning valve separates the exhaled air into three fractions beginning with the earliest portion of upper respiratory air and continuing to the terminal fraction of deep lung air. The same volumetric fractions from successive exhalations are collected over a test period of any practical duration. In principle, the apparatus is similar to one previously described (Rev. Sci. Instr. 22, 81, 1951) for the study of dust retention in human lungs.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.