The duration of electrocardiograph wave forms and intervals were determined in 179 Spanish-bred (Andalusian) horses aged from 1 month to 17 years. The values were compared with those of other breeds, and the relationship between electrocardiographic data and age was examined. High correlation coefficients were found between PR, ST and QT intervals and the age of the horses, and an inverted relation between heart rate and age was found. A multiple range analysis was made and the results suggest that significant changes in duration values and heart rate occurred at the age of 6 months and in the second year of life.
RESUMENLas cojeras constituyen la principal causa de consulta en clínica equina y la osteoartritis (OA) representa cerca del 60 % de los casos. Durante la última década se han presentado avances significativos en nuestro entendimiento de la fisiopatología de la OA. Sin embargo, se ha avanzado muy poco en el desarrollo de tratamientos efectivos que no solo alivien el dolor y la inflamación asociados al problema, sino que también limiten los cambios degenerativos o incluso promuevan la regeneración de los tejidos articulares afectados por esta enfermedad crónica inflamatoria. Por otra parte, estos tratamientos deberían ser libres de efectos adversos como trastornos gastrointestinales, daño renal e inmunosupresión. El actual conocimiento de proteínas y células comprometidas en la biología de las enfermedades musculo-esqueléticas, como la OA, han permitido el desarrollo de nuevos enfoques terapéuticos desde el punto de vista experimental y clínico. El objetivo de esta revisión es presentar estado del arte de la terapia regenerativa articular en el caballo.Palabras clave: caballo, osteoartritis, medicina regenerativa. SUMMARYLameness is the main cause of consultation in the current equine clinic, and osteoarthritis (OA) represents about 60% of cases. During the last decade, there have been significant advances in our understanding of the pathophysiology of OA. However, there has been little progress in the development of effective treatments that not only relieve pain and inflammation associated with the problem, but also limit degenerative changes, or even promote regeneration in joint tissues affected by this chronic and inflammatory disease. These treatments should be free of side effects such as gastrointestinal disorders, kidney damage and immunosuppression. Current knowledge about the proteins and cells involved in the biology of musculoskeletal diseases, such as OA, has allowed the development of new therapeutic approaches from an experimental and clinical viewpoint. The aim of this review is to present the state of the art for regenerative therapy of joints in the horse.
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