1 Subepidermal injection of histamine solutions in isotonic saline in four subjects evoked whealing after a mean delay of 2.6 min, this estimate being derived by regression modelling. 2 Wheal growth was better modelled by the logarithm of time than by time, suggesting that wheal size depends upon assisted diffusion of histamine in the dermis. 3 Wheal growth was piecemeal, not continuous, consistent with the successive involvement of neighbouring vascular territories. 4 Wheal growth was completed by 9 min after injection.
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