The topometric coordinate system of gray and white matter has been determined on photographs of human spinal cord section. The x-axis in the coordinate system represents the contact line with the funiculi posteriores, while the y-axis runs through the sulcus medianus posterior, in which the initial values are 0/0. Certain structures of the gray matter and the white matter have been marked on photographs of the cervical spinal cord and segment S2. The photographs obtained may serve as model maps for spinal cord stereotaxis.
1. The high-resolution 1H NMR (MRS) spectra of human brain tumor homogenates revealed a broad resonance at 5.3-5.4 ppm in glioblastoma multiforme (N = 16) and brain metastases (N = 3). The broad resonance was identified as ceramide, a sphingosine-fatty acid combination portion of ganglioside, indicating an elevated abundance of monounsaturated fatty acids. GLC analysis of gangliosides in the highly malignant glioblastoma multiforme revealed that the elevated monounsaturated fatty acid is oleic acid (C18:1). The resonance at 5.3-5.4 ppm region was not detectable in normal human brain (N = 2), in meningiomas (N = 2), or in low-grade astrocytomas (N = 12). In normal human brain the abundance of monounsaturated fatty acid is minimal. 2. This investigation was made possible because the method of producing homogenate resulted in (i) no loss of lipids during the process and (ii) a well-homogenised sample, with (iii) no loss in chemical integrity. 3. The properties of tumor gangliosides include antigenic specificity and immunosuppressive activity and the ceramide, a sphingosine-fatty acid combination, noticeably influences the ganglioside immunosuppressive activity. 4. The observation of 1H NMR ceramide resonance in high-malignant brain tumors emphasizes the dramatic role of aberant gangliosides and ceramide precursors on the grade of malignancy and invasiveness. 5. Further insight into the specific nature of the ceramide portion of gangliosides in grading the malignancy of brain tumors should be investigated further.
A method of measuring the cross-section areas of some structures of the human spinal cord is described for the purpose of obtaining the coordinate values by means of simultaneously photographing the transverse section of the spinal cord, together with a microscopic objective square raster. The obtained coordinate values have been processed by means of a computer and represent the statistical model map of some structures of the human spinal cord. By means of the present method, the classic anatomical and topometrical figure of the spinal cord is converted to a coordinate system that may be defined mathematically.
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