Mass spectrometry continues to drive the field of lipidomics across many areas of research because of its unique capability for characterizing lipids. With an accurate molecular weight, often in combination with ion mobility or liquid chromatography, MS can deconstruct a complex mixture of lipids into a table of lipid species annotated by class and isobar. Tandem MS, typically low energy CID, can further distinguish isobars by the different fatty acid fragments and in some cases reveal the fatty acid bonding position. In the Special Feature Kane and coworkers at University of Maryland apply a new electron‐induced dissociation technique to singly‐charged mono‐ and di‐unsaturated phospholipids and show how the resulting fragmentation patterns indicate the fatty acid position as well as the double bond location.
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