Deoxypumiliotoxin 251H [4], representing a new subclass of the pumiliotoxin-A class of alkaloids, has been isolated from a dendrobatid frog, Epipedobates tricolor. The structure, elucidated by nmr, gc-Ftir, and mass spectral analyses, is proposed to be an 8-methyl-6-(5-hydroxy-2-methylhexylidene)-1-azabicyclo[4.3.0]nonan e. The absolute stereochemistry and the relative configuration of the hydroxyl group are unknown.
Alkaloids U 0600 Enantioselective Syntheses of Two Diastereomers of 223V, an Alkaloid from the Poison Frog Dendrobates pumilio. -Both synthesized indolizidines (I) and (II) do not correspond to the natural alkaloid 223I. A previously synthesized indolizidine (III) is found to be identical to alkaloid 223V. -(TOYOOKA*, N.; NEMOTO, H.; KAWASAKI, M.; GARRAFFO, H. M.; SPANDE, T. F.; DALY, J. W.; Tetrahedron 61 (2005) 5, 1187-1198; Fac. Pharm. Sci., Toyama Med. Pharm. Univ., Toyama 930, Japan; Eng.) -Klein 24-190
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.